Topical Dutasteride

Topical dutasteride is another off-label treatment option for androgenic alopecia. Like topical finasteride, it works by inhibiting the conversion of testosterone to DHT. However, topical dutasteride blocks both type 1 and type 2 5-alpha reductase enzymes, which makes it a more potent DHT blocker than topical finasteride.

Topical dutasteride is not approved by the FDA for the treatment of hair loss, but some compounding pharmacies prepare it as a prescription medication for topical use. The FDA does not regulate compounded medications, so the safety and efficacy of these formulations may vary.

Studies have shown that topical dutasteride can effectively reduce scalp DHT levels and improve hair growth. One study published in the Journal of Dermatological Treatment found that a 0.1% dutasteride solution applied topically twice a week for six months led to significant improvements in hair count and thickness in men with androgenic alopecia. Another study published in the Journal of the American Academy of Dermatology reported that a topical dutasteride gel applied once daily for six months resulted in a significant reduction in serum DHT levels and hair regrowth in women with female pattern hair loss.

While topical dutasteride may be effective for hair loss, it also has a greater potential for adverse side effects compared to topical finasteride. As with oral dutasteride, there is a risk of sexual dysfunction, breast tenderness and enlargement, and depression. It is important to discuss the risks and benefits of this treatment option with a qualified healthcare professional before use.

Used for: Male Pattern Baldness